Great Smoky Mountains National Park, USA sprawls over the ridgeline of the Great Smoky Mountains and part of the Blue Ridge Mountains, which are a division of the larger Appalachian Mountain chain. The border between Tennessee and North Carolina runs northeast to southwest through the middle of the park. The Great Smoky Mountains National Park, USA is the most visited national park of the United States. On its route from Maine to Georgia, the Appalachian Trail also passes through the center of the park.

The Great Smoky Mountains National Park, USA encompasses 814 square miles (2,108 km²), making it one of the largest protected areas in the eastern United States. The main entrances of the park are located along U.S. Highway 441 (Newfound Gap Road) at the towns of Gatlinburg, Tennessee, and Cherokee, North Carolina.

The Great Smoky Mountains National Park is a major tourist attraction in United States of America. The park is visited by over 9 million tourists and 11 million non-recreational visitors throughout the year. Surrounding towns, notably Gatlinburg, Pigeon Forge, Sevierville, and Townsend, Tennessee, and Cherokee, Sylva, Maggie Valley, and Bryson City, North Carolina receive a significant portion of their income from tourism associated with the park. The two main visitors' centers inside the park are Sugarlands Visitors' Center near the Gatlinburg entrance to the park and Oconaluftee Visitors' Center near Cherokee, North Carolina at the eastern entrance to the park.

The various activities inside the park include:
Auto Touring
Bicycling
Camping
Fishing
Hiking
Historic Buildings
Horseback Riding
Picnicking
Waterfalls
Wildflowers